KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
9.39
Human Site:
S711
Identified Species:
17.22
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
S711
S
L
S
L
F
H
P
S
N
V
E
M
L
S
S
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
V694
F
S
I
L
V
H
C
V
N
V
E
M
L
S
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
F673
S
L
I
F
W
I
P
F
S
I
L
V
H
C
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
S711
S
L
S
L
F
H
H
S
N
I
E
M
L
S
S
Rat
Rattus norvegicus
Q9Z1K9
827
92999
S711
S
L
S
L
F
H
H
S
N
I
E
M
L
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
Q318
S
P
C
C
K
N
C
Q
F
E
T
A
Q
K
K
Chicken
Gallus gallus
NP_001008682
829
93588
E716
L
F
C
A
S
N
A
E
V
P
S
S
L
D
S
Frog
Xenopus laevis
Q8JIY1
749
84049
C633
T
L
Q
P
G
S
P
C
N
E
F
K
G
Y
C
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
Y708
L
S
T
K
P
L
F
Y
P
S
N
A
E
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
T620
P
D
V
L
P
D
G
T
P
C
I
T
G
F
C
Honey Bee
Apis mellifera
XP_623993
716
82155
P604
I
D
P
Q
D
I
L
P
D
G
T
P
C
I
Q
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
R574
E
D
L
E
L
S
C
R
L
C
C
R
D
Y
N
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
R650
V
H
Y
V
D
K
K
R
A
R
E
L
K
Q
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
60
N.A.
20
N.A.
86.6
86.6
N.A.
6.6
13.3
20
0
N.A.
6.6
0
0
6.6
P-Site Similarity:
100
60
N.A.
46.6
N.A.
93.3
93.3
N.A.
13.3
20
26.6
6.6
N.A.
13.3
6.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
0
8
0
0
16
0
0
0
% A
% Cys:
0
0
16
8
0
0
24
8
0
16
8
0
8
8
16
% C
% Asp:
0
24
0
0
16
8
0
0
8
0
0
0
8
8
0
% D
% Glu:
8
0
0
8
0
0
0
8
0
16
39
0
8
0
0
% E
% Phe:
8
8
0
8
24
0
8
8
8
0
8
0
0
8
0
% F
% Gly:
0
0
0
0
8
0
8
0
0
8
0
0
16
0
0
% G
% His:
0
8
0
0
0
31
16
0
0
0
0
0
8
0
0
% H
% Ile:
8
0
16
0
0
16
0
0
0
24
8
0
0
8
8
% I
% Lys:
0
0
0
8
8
8
8
0
0
0
0
8
8
8
8
% K
% Leu:
16
39
8
39
8
8
8
0
8
0
8
8
39
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
31
0
0
0
% M
% Asn:
0
0
0
0
0
16
0
0
39
0
8
0
0
0
8
% N
% Pro:
8
8
8
8
16
0
24
8
16
8
0
8
0
0
0
% P
% Gln:
0
0
8
8
0
0
0
8
0
0
0
0
8
8
8
% Q
% Arg:
0
0
0
0
0
0
0
16
0
8
0
8
0
0
0
% R
% Ser:
39
16
24
0
8
16
0
24
8
8
8
8
0
31
39
% S
% Thr:
8
0
8
0
0
0
0
8
0
0
16
8
0
0
0
% T
% Val:
8
0
8
8
8
0
0
8
8
16
0
8
0
0
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
8
0
0
0
0
0
16
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _